Clinicopathologic and Molecular Features of Colorectal Adenocarcinoma with Signet-Ring Cell Component

Clinicopathologic and Molecular Features of Colorectal Adenocarcinoma with Signet-Ring Cell Component

BACKGROUND We performed a retrospective study to assess the clinicopathological characters, molecular alterations and multigene mutation profiles in colorectal cancer patients with signet-ring cell component. METHODS Between November 2008 and January 2015, 61 consecutive primary colorectal carcinomas with signet-ring cell component were available for pathological confirmation. RAS/BRAF status...

BRAF mutation in colorectal carcinomas with signet ring cell component

OBJECTIVE : Signet ring cell carcinoma is a rare subtype of colorectal carcinoma (CRC) with an associated BRAFV600E mutation. We investigated frequencies of BRAF mutation in 28 CRCs containing variable signet ring cell component and their relation with clinicopathologic parameters. METHODS : According to the presence of signet ring cell component, tumors were categorized into groups as follow...

Correlation of multiple proteins with clinic-pathological features and its prognostic significance in colorectal cancer with signet-ring cell component.

OBJECTIVE Primary colorectal cancer (CRC) with signet-ring cell (SRC) component is a distinct tumor of colon and rectum, and its prognosis is very poor. Reliable markers to predict the poor clinical outcome of this subgroup cancer remains undetermined. Therefore, we perform this study to investigate the prognosis value of seven proteins in CRC with SRC component . PATIENTS AND METHODS This st...

Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma.

We present the case report of a twenty-five-year-old Moroccan male patient who suffered from leptomeningeal carcinomatosis related to a signet-ring cell carcinoma of the rectum. He presented to the emergency department with abdominal pain, constipation, weight loss and rectal bleeding. The rectal examination showed a rectal tumor and a CT scan revealed a large bowel obstruction due to rectal di...

Signet-ring cell carcinoma of colorectum – current perspectives and molecular biology REVIEW: Running title: Colorectal signet-ring carcinoma